Guerbet To Spotlight The Novel New Drug Elucirem (gadopiclenol) Injection At RSNA22

November 26, 2022 – Guerbet LLC, the US subsidiary of Guerbet, a world chief in medical imaging that provides a complete line of pharmaceutical merchandise, medical units and digital and synthetic intelligence (AI) options for diagnostic and interventional imaging, will current knowledge on Elucirem (gadopiclenol) injection, Dotarem (gadoterate meglumine) injection and AI options at the 2022 Radiological Society of North America (RSNA) Scientific Meeting and Annual Meeting.

“It is very exciting to be back at RSNA, to give the radiology community a first-hand opportunity to experience the clarity of MRI images offered by our new MRI product, Elucirem,” mentioned David Hale, Chief Executive Officer of the Guerbet Group, mentioned. “We look forward to sharing insights into gadopiclenol, a new, highly stable macrocyclic gadolinium-based contrast agent that offers the highest relaxation capability in its class for magnetic resonance imaging.²“

Elucirem is indicated to be used with MRI in adults and pediatric sufferers two years of age and older to detect lesions in the central nervous system (mind, backbone and related tissues) and the physique (head and neck, thorax, stomach, pelvis and musculoskeletal and to visualize) system).¹

For Elucirem, Guerbet obtained Priority Review by the US Food and Drug Administration (FDA) based mostly on the unmet medical wants, as there are at the moment no US accepted and marketed MRI distinction brokers indicated for musculoskeletal lesion visualization and no macrocyclic GBCAs broadly accepted to visualize lesions positioned all through the physique.³Guerbet obtained US FDA advertising approval for Elucirem on September 21, 2022.

Elucirem (gadopiclenol) injection shall be accessible in glass vials, glass pharmacy bulk packages and in plastic prefilled syringes, which might help streamline workflow in the imaging suite. All gadopiclenol is manufactured by Guerbet Group Company.

ELUCIREM (gadopiclenol) Injection and DOTAREM (gadoterate meglumine) Injection Important Safety Information

WARNING: Nephrogenic systemic fibrosis (NSF)

See full prescribing info for full field warning

Gadolinium-based distinction brokers (GBCAs) enhance the threat of NSF amongst sufferers with impaired elimination of the brokers. Avoid the use of GBCAs in these sufferers until the diagnostic info is crucial and never accessible with non-contrast MRI or different modalities.

The threat for NSF seems highest amongst sufferers with:
- Chronic, extreme kidney illness (GFR <30 ml/min/1.73 m²), or
- Acute kidney damage.
Screen sufferers for acute kidney damage and different circumstances which will scale back kidney operate. For sufferers at threat for chronically lowered renal operate (for instance, age >60 years, hypertension or diabetes), estimate the glomerular filtration price (GFR) by laboratory checks.

Opportunities to be taught extra at RSNA 2022

RSNA Innovation Theater — @ 1:00 PM – 1:15 PM CST, Monday November 28, 2022: Aashim Bhatia, MD, MS, Assistant Professor of Radiology and Pediatric Neuroradiologist at the Children’s Hospital of Philadelphia will current Guerbet’s newest innovation: illuminates the potentialities with a novel new drug https://eppro02.ativ.me/web/planner.?id=RSNA22&table=agenda&tid=S1138

Oral and poster displays:

Title	Author(s)	Date Time	Session quantity
Reduced physique gd publicity over 5 months after a single human equal dose of gadopiclenol in contrast to gadobutrol in wholesome rats	M. Rasschaert, C. Eoulourmyl Strzeminska, C. Walton, M. Lefebvre, N. Decout, C. Factor, P. Robert	December 1 – 12:15 – 12:45	RSA-SPNPM
Efficacy and security of gadopiclenol for central nervous system (CNS) magnetic resonance imaging (MRI): The Picture Trial	Leo Wolansky	Nov 30 13:30 – 14:30	W6 – SSNR13
Efficacy and security of gadopiclenol for the central nervous system (CNS) magnetic resonance imaging (MTI): The Picture Trial	Christian Kuhl	Nov 27 14:30 – 15:30	S5 – SSMSO1
Use of real-world security knowledge from worldwide pharmacovigilance databases to assess the significance of signs related to gadolinium publicity	Imran Shahid, Eric Lancelot	December 1st 12:15 – 12:45	R5A – SPNR
Super-dose: a deep studying technique to enhance the sensitivity of MRI in neuro-oncology by way of digital dose amplification	Alexandre Bone Dr. Samy Ammari	Thu. Nov 30 12:45 – 1:15 p.m	W5B – SPNR
Multi-head deep studying mannequin for detection of prostate most cancers lesions in bi-parametric MRI	Kourosh Jafari-Khouzani, Maria Victoria Sainz de Cea, Wen Wei, Aly Mohamed, Noelle Debs, Alexandre Routier, Onofrio Caralano, Marwan Sati, Amin Katouzian	Tues 29 Nov 12:45 – 1:15 p.m Scientific poster periods	Learning Center – IN DPS T5B-SPIN-4
Comparison of three strategies for lesion detection and classification on bi-parametric MRI	Maria V. Sainz de Cea, Kourosh Jafari-Khouzani, Wen Wei, Aly A. Mohamed, Noelie Debs, Alexandre Routier, Marc-Michel Rohe, Russell Klenk, Onofrio Catalano, Amin Katouzian	Tues 29 Nov 9:00 am – 9:30 am Scientific poster periods	Learning Center – GU DPS T2-SPGU-3
Rigorous Comparison of a New Fully Automated Deep Learning Algorithm for Focal Liver Lesions Detection in Abdominal Contrast CT with Radiologists	Dufort, G. Palma, PL Esquinas Fernandez, Y. Wang, O. Bonakdar Sakhi, FC Commander, A. Sitek, F. Louvet-De Verchere, Okay. Siewert, Okay. Tipton	Tues 29 Nov 13:30 – 14:30	S401 T6-SSGI10-4

Guerbet’s RSNA Education and Research Award recipient 2022

As a part of its continued partnership with the Radiological Society of North America (RSNA), Guerbet is proud to announce that the RSNA Research & Education (R&E) Foundation Board of Trustees has awarded the Guerbet Research Scholar Grant to Vivek Yedavalli, MD, MS awarded from Johns Hopkins School of Medicine. Dr. Yedavalli was awarded $75,000 per yr for 2 years to help his research, Deep studying fashions utilizing baseline complete CT stroke collateral imaging in cerebral angiographic collaterals, post-procedural hemorrhagic transformation, and medical outcomes predictions for growing thrombectomy eligibility. The RSNA R&E Foundation invests in the way forward for radiology by creating investigators and supporting lifelong modern analysis and training.

Digital options Show at Booth #1711

Guerbet may even characteristic a set of digital and AI software-based merchandise that assist shut the loop with the good connection between monitoring and reporting:

Dosage & Carea contemporary digital answer for monitoring affected person publicity to X-rays that’s appropriate with all kinds of ionizing modalities and collects knowledge to present a report of affected person publicity
Contrast and carean injection knowledge administration answer that permits imaging facilities to acquire, archive, study and share injection knowledge, together with knowledge on distinction merchandise, hostile occasions, injector exercise, info on estimated glomerular filtration price and different threat components prior to a medical examination
Icon minda cloud-based AI answer designed to quantify disease-specific mind constructions on MR and CT
Galileoan academic web-based case evaluate platform to assist practice radiology residents.

For extra info: www.guerbet.com

Find extra RSNA22 protection right here